Antidepressants Not Clinically Useful for Back Pain (madinamerica.com)


A very helpful article on the limitations of tablets like duloxetine (SSNRI) on managing chronic back pain.

They are prescribed based on the notion that some of the pain has become “centralised” meaning tha the longstanding nature of pain has led to neural changes in the processing centres of the spinal cord and brain (see animations at www.ACTforPAIN.com for more information on centralisation of pain).